Biphenyl & Diphenyl ether;(intermediate of telmisartan);Biphenyl derivatives;(intermediate of sartan);(intermediate of sartan s product);Losartan Potassium;Starting Raw Materials & Intermediates;INTERMEDIATESOF;Chiral Compound;Hypertension;Building block;Liquid Crystals;Organic Electronics and Photonics;cyanide;114772-53-1
4'-Methylbiphenyl-2-carbonitrile is an intermediate in the synthesis of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase 3 .
4'-Methyl-2-cyanobiphenyl is prepared by the reaction of o-cyanobromobenzene and potassium (4-methylphenyl)trifluoroborate. The specific synthesis steps are as follows: General procedure: A mixture of aryl halide ({{0}}.5 mmol), potassium aryltrifluoroborate (0.6 mmol), K2CO3 (1.0 mmol), Pd/C (5%; 0.5 mol%), ethanol (3 mL), and distilled water (1 mL) was stirred at 80 degree in air for the time indicated. The reaction mixture was added to brine (15 mL) and extracted with ethyl acetate (4×15 mL). The organic solvent was removed under vacuum, and the product was isolated by short-column chromatography.
4'-Methyl-2-cyanobiphenyl Preparation Products And Raw materials
